ABSTRACT
Gitelman syndrome is an autosomal recessive hereditary disorder characterized by hypokalemic metabolic alkalosis, hypomagnesemia, salt wasting, low blood pressure, and hypocalciuria. Gitelman's syndrome is generally considered to be benign, and muscle weakness may be the only manifestation of hypokalemia. To our knowledge, there have been no case reports of rhabdomyolysis due to severe hypokalemia of Gitelman's syndrome in Korea. We report a case of Gitelman's like syndrome presenting with paralysis of both lower extrimities and myalgia. Rhabdomyolysis caused by severe hypokalemia was diagnosed and recovered with supportive therapy, including the administration of 0.9% normal saline and KCl.
Subject(s)
Alkalosis , Gitelman Syndrome , Hypokalemia , Hypotension , Korea , Muscle Weakness , Myalgia , Paralysis , RhabdomyolysisABSTRACT
Non-albicans Candida species which are resistant to azole are emerging as important pathogens in patients with hematological malignancies who received antifungal prophylaxis. C. inconspicua is one of rare Candida spp. and resistant to fluconazole and deep infection due to C. inconspicua has not been reported in Korea so far. We reported here two cases of candidemia due to C. inconspicua in neutropenic patients with acute leukemia. C. inconspicua were presumed to be originated from gastrointestinal tract in both cases. The antifungal susceptibility test of C. inconspicua in case 1 showed resistance to fluconazole and itraconazole. Both cases were successfully treated by amphotericin B deoxycholate. Clinicians should keep in mind that non-albicans Candida species would be emerging pathogen in immunocompromised hosts and early recognition and appropriate use of antifungal agents is necessary.
Subject(s)
Humans , Amphotericin B , Antifungal Agents , Candida , Candidemia , Danazol , Deoxycholic Acid , Fluconazole , Fungemia , Gastrointestinal Tract , Hematologic Neoplasms , Immunocompromised Host , Itraconazole , Korea , Leukemia , NeutropeniaABSTRACT
Non-albicans Candida species which are resistant to azole are emerging as important pathogens in patients with hematological malignancies who received antifungal prophylaxis. C. inconspicua is one of rare Candida spp. and resistant to fluconazole and deep infection due to C. inconspicua has not been reported in Korea so far. We reported here two cases of candidemia due to C. inconspicua in neutropenic patients with acute leukemia. C. inconspicua were presumed to be originated from gastrointestinal tract in both cases. The antifungal susceptibility test of C. inconspicua in case 1 showed resistance to fluconazole and itraconazole. Both cases were successfully treated by amphotericin B deoxycholate. Clinicians should keep in mind that non-albicans Candida species would be emerging pathogen in immunocompromised hosts and early recognition and appropriate use of antifungal agents is necessary.